TLE2 (NM_003260) Human Recombinant Protein

Product Specifications

Background

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity) .[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human transducin-like enhancer of split 2 (E (sp1) homolog, Drosophila) (TLE2), transcript variant 1

Synonyms

ESG; ESG2; GRG2

Gene ID

7089

UniProt

Q04725

Accession Number mRNA

NM_003260

Chromosomal Location

19p13.3

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Transcription Factors

Molecular Weight

79.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.