PPP3CC (NM_005605) Human Recombinant Protein
Product Specifications
Background
Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Synonyms
CALNA3; CNA3; PP2Bgamma
Gene ID
5533
UniProt
P48454
Accession Number mRNA
NM_005605
Chromosomal Location
8p21.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Axon guidance, B cell receptor signaling pathway, Calcium signaling pathway, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, T cell receptor signaling pathway, VEGF signaling pathway, Wnt signaling pathway
Field of Research
Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Axon guidance, B cell receptor signaling pathway, Calcium signaling pathway, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, T cell receptor signaling pathway, VEGF signaling pathway, Wnt signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Phosphatase
Molecular Weight
57.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PPP3CC
Species
Human
Protein ID
NP_005596
Overview
Recombinant protein of human protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (PPP3CC)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5533
Uniprot URL
https://www.uniprot.org/uniprot/P48454
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005605
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005596
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