KEAP1 (NM_012289) Human Recombinant Protein
Product Specifications
Background
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human kelch-like ECH-associated protein 1 (KEAP1), transcript variant 2
Synonyms
INrf2; KLHL19
Gene ID
9817
UniProt
Q14145, A0A024R7C0
Accession Number mRNA
NM_012289
Chromosomal Location
19p13.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Ubiquitin mediated proteolysis
Field of Research
Ubiquitin mediated proteolysis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transcription Factors
Molecular Weight
69.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
KEAP1
Species
Human
Protein ID
NP_036421
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9817
Uniprot URL
https://www.uniprot.org/uniprot/Q14145
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_012289
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_036421
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