CHST12 (NM_018641) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. Alternatively spliced transcript variants differing only in their 5' UTRs have been found for this gene. [provided by RefSeq, Aug 2011]

Overview

Recombinant protein of human carbohydrate (chondroitin 4) sulfotransferase 12 (CHST12)

Synonyms

C4S-2; C4ST-2; C4ST2

Gene ID

55501

UniProt

Q9NRB3, A0A024R860

Accession Number mRNA

NM_018641

Chromosomal Location

7p22.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Chondroitin sulfate biosynthesis, Sulfur metabolism

Field of Research

Chondroitin sulfate biosynthesis, Sulfur metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Transmembrane

Molecular Weight

48.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.