Apc10 (ANAPC10) (NM_014885) Human Recombinant Protein
Product Specifications
Background
ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]) .[supplied by OMIM, Feb 2011]
Overview
Recombinant protein of human anaphase promoting complex subunit 10 (ANAPC10)
Synonyms
APC10; DOC1
Gene ID
10393
UniProt
Q9UM13
Accession Number mRNA
NM_014885
Chromosomal Location
4q31.21
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation, Ubiquitin mediated proteolysis
Field of Research
Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation, Ubiquitin mediated proteolysis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
21.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ANAPC10
Species
Human
Protein ID
NP_055700
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/10393
Uniprot URL
https://www.uniprot.org/uniprot/Q9UM13
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014885
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055700
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