C1orf41 (HSPB11) (NM_016126) Human Recombinant Protein
Product Specifications
Background
Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
C1orf41; FAP232; HSPCO34; IFT25; PP25
Gene ID
51668
UniProt
Q9Y547
Accession Number mRNA
NM_016126
Chromosomal Location
1p32.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
16.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
HSPB11
Species
Human
Protein ID
NP_057210
Overview
Recombinant protein of human heat shock protein family B (small), member 11 (HSPB11)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/51668
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y547
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_016126
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_057210
Curated Selection
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