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NDUFS4 (NM_002495) Human Recombinant Protein

Product Specifications

Background

This gene encodes an nuclear-encoded accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I, or NADH:ubiquinone oxidoreductase) . Complex I removes electrons from NADH and passes them to the electron acceptor ubiquinone. Mutations in this gene can cause mitochondrial complex I deficiencies such as Leigh syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Synonyms

AQDQ; CI-18; CI-18 kDa; CI-AQDQ; MC1DN1

Gene ID

4724

UniProt

O43181, A0A0S2Z433

Accession Number mRNA

NM_002495

Chromosomal Location

5q11.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Alzheimer's disease, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

Field of Research

Alzheimer's disease, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

15.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

NDUFS4

Species

Human

Protein ID

NP_002486

Overview

Recombinant protein of human NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) (NDUFS4), nuclear gene encoding mitochondrial protein

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/4724

Uniprot URL

https://www.uniprot.org/uniprot/O43181

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_002495

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_002486

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