UBC6e (UBE2J1) (NM_016021) Human Recombinant Protein
Product Specifications
Background
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) (UBE2J1)
Synonyms
CGI-76; HSPC153; HSPC205; HSU93243; NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p
Gene ID
51465
UniProt
Q9Y385
Accession Number mRNA
NM_016021
Chromosomal Location
6q15
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Parkinson's disease, Ubiquitin mediated proteolysis
Field of Research
Parkinson's disease, Ubiquitin mediated proteolysis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transmembrane
Molecular Weight
35 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
UBE2J1
Species
Human
Protein ID
NP_057105
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/51465
Uniprot URL
https://www.uniprot.org/uniprot/Q9Y385
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_016021
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_057105
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