SIRT6 (NM_016539) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Synonyms
SIR2L6
Gene ID
51548
UniProt
Q8N6T7
Accession Number mRNA
NM_016539
Chromosomal Location
19p13.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transcription Factors
Molecular Weight
38.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SIRT6
Species
Human
Protein ID
NP_057623
Overview
Recombinant protein of human sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) (SIRT6)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/51548
Uniprot URL
https://www.uniprot.org/uniprot/Q8N6T7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_016539
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_057623
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