THG1L (NM_017872) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of this protein is that of a guanyltransferase, adding GMP to the 5' end of tRNA (His) . Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Synonyms
HTHG1; ICF45; IHG-1; IHG1; SCAR28; THG1
Gene ID
54974
UniProt
Q9NWX6
Accession Number mRNA
NM_017872
Chromosomal Location
5q33.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
34.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
THG1L
Species
Human
Protein ID
NP_060342
Overview
Recombinant protein of human tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) (THG1L)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/54974
Uniprot URL
https://www.uniprot.org/uniprot/Q9NWX6
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_017872
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_060342
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