THG1L (NM_017872) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of this protein is that of a guanyltransferase, adding GMP to the 5' end of tRNA (His) . Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Overview

Recombinant protein of human tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) (THG1L)

Synonyms

HTHG1; ICF45; IHG-1; IHG1; SCAR28; THG1

Gene ID

54974

UniProt

Q9NWX6

Accession Number mRNA

NM_017872

Chromosomal Location

5q33.3

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

34.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.