PMVK (NM_006556) Human Recombinant Protein
Product Specifications
Background
This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Synonyms
HUMPMKI; PMK; PMKA; PMKASE; POROK1
Gene ID
10654
UniProt
Q15126, Q6FGV9
Accession Number mRNA
NM_006556
Chromosomal Location
1q21.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Metabolic pathways, Terpenoid backbone biosynthesis
Field of Research
Metabolic pathways, Terpenoid backbone biosynthesis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
21.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PMVK
Species
Human
Protein ID
NP_006547
Overview
Recombinant protein of human phosphomevalonate kinase (PMVK)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/10654
Uniprot URL
https://www.uniprot.org/uniprot/Q15126
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_006556
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_006547
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