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PMVK (NM_006556) Human Recombinant Protein

Product Specifications

Background

This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Overview

Recombinant protein of human phosphomevalonate kinase (PMVK)

Synonyms

HUMPMKI; PMK; PMKA; PMKASE; POROK1

Gene ID

10654

UniProt

Q15126, Q6FGV9

Accession Number mRNA

NM_006556

Chromosomal Location

1q21.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Metabolic pathways, Terpenoid backbone biosynthesis

Field of Research

Metabolic pathways, Terpenoid backbone biosynthesis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

21.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

PMVK

Species

Human

Protein ID

NP_006547

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/10654

Uniprot URL

https://www.uniprot.org/uniprot/Q15126

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_006556

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_006547

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