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MMP9 (NM_004994) Human Recombinant Protein

Product Specifications

Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (MMP9)

Synonyms

CLG4B; GELB; MANDP2; MMP-9

Gene ID

4318

UniProt

P14780

Accession Number mRNA

NM_004994

Chromosomal Location

20q13.12

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Bladder cancer, Leukocyte transendothelial migration, Pathways in cancer

Field of Research

Bladder cancer, Leukocyte transendothelial migration, Pathways in cancer

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protease

Molecular Weight

78.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

MMP9

Species

Human

Protein ID

NP_004985

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/4318

Uniprot URL

https://www.uniprot.org/uniprot/P14780

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_004994

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_004985

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