PCBD1 (NM_000281) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Synonyms
DCOH; PCBD; PCD; PHS
Gene ID
5092
UniProt
P61457
Accession Number mRNA
NM_000281
Chromosomal Location
10q22.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
11.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PCBD1
Species
Human
Protein ID
NP_000272
Overview
Recombinant protein of human pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5092
Uniprot URL
https://www.uniprot.org/uniprot/P61457
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000281
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000272
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