ZKSCAN3 (NM_024493) Human Recombinant Protein
Product Specifications
Background
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas.[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human zinc finger with KRAB and SCAN domains 3 (ZKSCAN3)
Synonyms
DJ874C20.1; dJ874C20.1.; ZF47; zfp-47; Zfp47; ZFP306; ZNF306; ZNF309; ZSCAN13; ZSCAN35
Gene ID
80317
UniProt
Q9BRR0
Accession Number mRNA
NM_024493
Chromosomal Location
6p22.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transcription Factors
Molecular Weight
60.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ZKSCAN3
Species
Human
Protein ID
NP_077819
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/80317
Uniprot URL
https://www.uniprot.org/uniprot/Q9BRR0
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_024493
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_077819
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