CES2 (NM_003869) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

Overview

Recombinant protein of human carboxylesterase 2 (intestine, liver) (CES2), transcript variant 1

Synonyms

CE-2; CES2A1; iCE; PCE-2

Gene ID

8824

UniProt

O00748

Accession Number mRNA

NM_003869

Chromosomal Location

16q22.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Drug metabolism - other enzymes

Field of Research

Drug metabolism - other enzymes

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

68.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.