CES2 (NM_003869) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
Synonyms
CE-2; CES2A1; iCE; PCE-2
Gene ID
8824
UniProt
O00748
Accession Number mRNA
NM_003869
Chromosomal Location
16q22.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Drug metabolism - other enzymes
Field of Research
Drug metabolism - other enzymes
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
68.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CES2
Species
Human
Protein ID
NP_003860
Overview
Recombinant protein of human carboxylesterase 2 (intestine, liver) (CES2), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8824
Uniprot URL
https://www.uniprot.org/uniprot/O00748
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003869
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003860
Curated Selection
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