IRAK4 (NM_016123) Human Recombinant Protein

Product Specifications

Background

This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Overview

Recombinant protein of human interleukin-1 receptor-associated kinase 4 (IRAK4), transcript variant 2

Synonyms

IMD67; IPD1; IRAK-4; NY-REN-64; REN64

Gene ID

51135

UniProt

Q9NWZ3, Q69FE3, B2RAP9, B4E359

Accession Number mRNA

NM_016123

Chromosomal Location

12q12

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Apoptosis, Neurotrophin signaling pathway, Toll-like receptor signaling pathway

Field of Research

Apoptosis, Neurotrophin signaling pathway, Toll-like receptor signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Protein Kinase

Molecular Weight

51.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.