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Myosin light chain 3 (MYL3) (NM_000258) Human Recombinant Protein

Product Specifications

Background

MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human myosin, light chain 3, alkali; ventricular, skeletal, slow (MYL3)

Synonyms

CMH8; MLC-lV/sb; MLC1SB; MLC1V; VLC1; VLCl

Gene ID

4634

UniProt

P08590, A0A024R2Q5

Accession Number mRNA

NM_000258

Chromosomal Location

3p21.31

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

Field of Research

Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

21.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

MYL3

Species

Human

Protein ID

NP_000249

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/4634

Uniprot URL

https://www.uniprot.org/uniprot/P08590

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000258

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000249

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