Cyclophilin B (PPIB) (NM_000942) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]
Synonyms
B; CYP-S1; CYPB; HEL-S-39; OI9; SCYLP
Gene ID
5479
UniProt
P23284
Accession Number mRNA
NM_000942
Chromosomal Location
15q22.31
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
20.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PPIB
Species
Human
Protein ID
NP_000933
Overview
Recombinant protein of human peptidylprolyl isomerase B (cyclophilin B) (PPIB)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5479
Uniprot URL
https://www.uniprot.org/uniprot/P23284
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000942
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000933
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