SQSTM1 (NM_003900) Human Recombinant Protein
Product Specifications
Background
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
Synonyms
A170; DMRV; FTDALS3; NADGP; OSIL; p60; p62; p62B; PDB3; ZIP3
Gene ID
8878
UniProt
Q13501
Accession Number mRNA
NM_003900
Chromosomal Location
5q35.3
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transcription Factors
Molecular Weight
47.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SQSTM1
Species
Human
Protein ID
NP_003891
Overview
Recombinant protein of human sequestosome 1 (SQSTM1), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8878
Uniprot URL
https://www.uniprot.org/uniprot/Q13501
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003900
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003891
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