Calreticulin (CALR) (NM_004343) Human Recombinant Protein
Product Specifications
Background
Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020]
Synonyms
CC1qR; CRT; HEL-S-99n; RO; SSA
Gene ID
811
UniProt
P27797, V9HW88
Accession Number mRNA
NM_004343
Chromosomal Location
19p13.13
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Antigen processing and presentation
Field of Research
Antigen processing and presentation
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Secreted Protein, Transcription Factors
Molecular Weight
46.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CALR
Species
Human
Protein ID
NP_004334
Overview
Recombinant protein of human calreticulin (CALR)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/811
Uniprot URL
https://www.uniprot.org/uniprot/P27797
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004343
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004334
Curated Selection
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