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FMO2 (NM_001460) Human Recombinant Protein

Product Specifications

Background

This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Overview

Recombinant protein of human flavin containing monooxygenase 2 (non-functional) (FMO2)

Synonyms

FMO1B1

Gene ID

2327

UniProt

Q99518, Q5JPC7

Accession Number mRNA

NM_001460

Chromosomal Location

1q24.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Drug metabolism - cytochrome P450

Field of Research

Drug metabolism - cytochrome P450

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

53.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

FMO2

Species

Human

Protein ID

NP_001451

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/2327

Uniprot URL

https://www.uniprot.org/uniprot/Q99518

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001460

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001451

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