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Tropomyosin 3 (TPM3) (NM_152263) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Synonyms

CAPM1; CFTD; HEL-189; HEL-S-82p; hscp30; NEM1; OK/SW-cl.5; TM-5; TM3; TM5; TM30; TM30nm; TPM3nu; TPMsk3; TRK

Gene ID

7170

UniProt

P06753

Accession Number mRNA

NM_152263

Chromosomal Location

1q21.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Thyroid cancer

Field of Research

Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Thyroid cancer

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

32.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

TPM3

Species

Human

Protein ID

NP_689476

Overview

Recombinant protein of human tropomyosin 3 (TPM3), transcript variant 1

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/7170

Uniprot URL

https://www.uniprot.org/uniprot/P06753

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_152263

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_689476

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