UBE2B (NM_003337) Human Recombinant Protein
Selected Variant
PH40419M5
Size: 20 µg
Product Specifications
Background
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human ubiquitin-conjugating enzyme E2B (RAD6 homolog) (UBE2B)
Synonyms
E2-17kDa; HHR6B; HR6B; RAD6B; UBC2
Gene ID
7320
UniProt
P63146
Accession Number mRNA
NM_003337
Chromosomal Location
5q31.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Ubiquitin mediated proteolysis
Field of Research
Ubiquitin mediated proteolysis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
17.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
UBE2B
Species
Human
Protein ID
NP_003328
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7320
Uniprot URL
https://www.uniprot.org/uniprot/P63146
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003337
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003328
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