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UBE2B (NM_003337) Human Recombinant Protein

Selected Variant

PH40419M5

Size: 20 µg

Product Specifications

Background

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human ubiquitin-conjugating enzyme E2B (RAD6 homolog) (UBE2B)

Synonyms

E2-17kDa; HHR6B; HR6B; RAD6B; UBC2

Gene ID

7320

UniProt

P63146

Accession Number mRNA

NM_003337

Chromosomal Location

5q31.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Ubiquitin mediated proteolysis

Field of Research

Ubiquitin mediated proteolysis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

17.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

UBE2B

Species

Human

Protein ID

NP_003328

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/7320

Uniprot URL

https://www.uniprot.org/uniprot/P63146

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_003337

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_003328

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