ASCC2 (NM_032204) Human Recombinant Protein
Product Specifications
Background
Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457) . Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347) .[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human activating signal cointegrator 1 complex subunit 2 (ASCC2)
Synonyms
ASC1p100; p100
Gene ID
84164
UniProt
Q9H1I8, A0A024R1F9
Accession Number mRNA
NM_032204
Chromosomal Location
22q12.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transcription Factors
Molecular Weight
86.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ASCC2
Species
Human
Protein ID
NP_115580
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/84164
Uniprot URL
https://www.uniprot.org/uniprot/Q9H1I8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_032204
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_115580
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