PCIF1 (NM_022104) Human Recombinant Protein
Product Specifications
Background
Cap-specific adenosine methyltransferase that catalyzes formation of N (6),2'-O-dimethyladenosine cap (m6A (m) ) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178) . Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A (m) co-transcriptionally (PubMed:30467178) . N6-methylation of m6A (m) promotes the translation of capped mRNAs (PubMed:30467178) .[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human PDX1 C-terminal inhibiting factor 1 (PCIF1)
Synonyms
C20orf67; CAPAM; hCAPAM; hPCIF1; PPP1R121
Gene ID
63935
UniProt
Q9H4Z3
Accession Number mRNA
NM_022104
Chromosomal Location
20q13.12
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
80.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PCIF1
Species
Human
Protein ID
NP_071387
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/63935
Uniprot URL
https://www.uniprot.org/uniprot/Q9H4Z3
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_022104
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_071387
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