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POLR1C (NM_203290) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Synonyms

AC40; HLD11; RPA5; RPA39; RPA40; RPAC1; RPC40; TCS3

Gene ID

9533

UniProt

O15160

Accession Number mRNA

NM_203290

Chromosomal Location

6p21.1

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Cytosolic DNA-sensing pathway, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, RNA polymerase

Field of Research

Cytosolic DNA-sensing pathway, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, RNA polymerase

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Stem cell - Pluripotency, Transcription Factors

Molecular Weight

39.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

POLR1C

Species

Human

Protein ID

NP_976035

Overview

Recombinant protein of human polymerase (RNA) I polypeptide C, 30kDa (POLR1C), transcript variant 1

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/9533

Uniprot URL

https://www.uniprot.org/uniprot/O15160

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_203290

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_976035

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