ATIC (NM_004044) Human Recombinant Protein

Product Specifications

Background

This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]

Overview

Recombinant protein of human 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC)

Synonyms

AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH

Gene ID

471

UniProt

P31939, V9HWH7

Accession Number mRNA

NM_004044

Chromosomal Location

2q35

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Metabolic pathways, One carbon pool by folate, Purine metabolism

Field of Research

Metabolic pathways, One carbon pool by folate, Purine metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Stem cell - Pluripotency

Molecular Weight

64.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.