Seladin 1 (DHCR24) (NM_014762) Human Recombinant Protein
Product Specifications
Background
This gene encodes a flavin adenine dinucleotide (FAD) -dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
Synonyms
DCE; Nbla03646; seladin-1; SELADIN1
Gene ID
1718
UniProt
Q15392
Accession Number mRNA
NM_014762
Chromosomal Location
1p32.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Metabolic pathways, Steroid biosynthesis
Field of Research
Metabolic pathways, Steroid biosynthesis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Stem cell - Pluripotency, Transmembrane
Molecular Weight
57.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
DHCR24
Species
Human
Protein ID
NP_055577
Overview
Recombinant protein of human 24-dehydrocholesterol reductase (DHCR24)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1718
Uniprot URL
https://www.uniprot.org/uniprot/Q15392
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014762
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055577
Curated Selection
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