Seladin 1 (DHCR24) (NM_014762) Human Recombinant Protein

Product Specifications

Background

This gene encodes a flavin adenine dinucleotide (FAD) -dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human 24-dehydrocholesterol reductase (DHCR24)

Synonyms

DCE; Nbla03646; seladin-1; SELADIN1

Gene ID

1718

UniProt

Q15392

Accession Number mRNA

NM_014762

Chromosomal Location

1p32.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Metabolic pathways, Steroid biosynthesis

Field of Research

Metabolic pathways, Steroid biosynthesis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Stem cell - Pluripotency, Transmembrane

Molecular Weight

57.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.