SETDB1 (NM_012432) Human Recombinant Protein

Product Specifications

Background

This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]

Overview

Purified recombinant protein of Homo sapiens SET domain, bifurcated 1 (SETDB1), transcript variant 2

Synonyms

ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21

Gene ID

9869

UniProt

Q15047

Accession Number mRNA

NM_012432

Chromosomal Location

1q21.3

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Lysine degradation

Field of Research

Lysine degradation

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

142.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.