SETDB1 (NM_012432) Human Recombinant Protein
Product Specifications
Background
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]
Synonyms
ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21
Gene ID
9869
UniProt
Q15047
Accession Number mRNA
NM_012432
Chromosomal Location
1q21.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Lysine degradation
Field of Research
Lysine degradation
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
142.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SETDB1
Species
Human
Protein ID
NP_036564
Overview
Purified recombinant protein of Homo sapiens SET domain, bifurcated 1 (SETDB1), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9869
Uniprot URL
https://www.uniprot.org/uniprot/Q15047
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_012432
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_036564
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