ACTC1 (NM_005159) Human Recombinant Protein
Product Specifications
Background
Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. Defects in this gene have been associated with idiopathic dilated cardiomyopathy (IDC) and familial hypertrophic cardiomyopathy (FHC) . [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human actin, alpha, cardiac muscle 1 (ACTC1)
Synonyms
ACTC; ASD5; CMD1R; CMH11; LVNC4
Gene ID
70
UniProt
P68032, B3KPP5
Accession Number mRNA
NM_005159
Chromosomal Location
15q14
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
Field of Research
Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
41.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ACTC1
Species
Human
Protein ID
NP_005150
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/70
Uniprot URL
https://www.uniprot.org/uniprot/P68032
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005159
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005150
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