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STAR (NM_000349) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Homo sapiens steroidogenic acute regulatory protein (STAR), nuclear gene encoding mitochondrial protein, transcript variant 1

Synonyms

STARD1

Gene ID

6770

UniProt

P49675, Q6IBK0

Accession Number mRNA

NM_000349

Chromosomal Location

8p11.23

Expression System

HEK293T

Tag

C-Myc/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

31.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

STAR

Species

Human

Protein ID

NP_000340

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/6770

Uniprot URL

https://www.uniprot.org/uniprot/P49675

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000349

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000340

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