Papillary renal cell carcinoma (PRCC) (NM_005973) Human Recombinant Protein
Product Specifications
Background
This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1) (p11; q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]
Overview
Recombinant protein of human papillary renal cell carcinoma (translocation-associated) (PRCC), transcript variant 1
Synonyms
RCCP1; TPRC
Gene ID
5546
UniProt
Q92733, A0A0S2Z456, Q96FT4
Accession Number mRNA
NM_005973
Chromosomal Location
1q23.1
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
52.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
PRCC
Species
Human
Protein ID
NP_005964
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5546
Uniprot URL
https://www.uniprot.org/uniprot/Q92733
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005973
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005964
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