CD14 (NM_000591) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020]
Overview
Recombinant protein of human CD14 molecule (CD14), transcript variant 1
Synonyms
CD14 antigen; CD14 molecule; monocyte differentiation antigen CD14
Gene ID
929
UniProt
P08571
Accession Number mRNA
NM_000591
Chromosomal Location
5q31.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Hematopoietic cell lineage, MAPK signaling pathway, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, Toll-like receptor signaling pathway
Field of Research
Hematopoietic cell lineage, MAPK signaling pathway, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, Toll-like receptor signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Transmembrane
Molecular Weight
38 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CD14
Species
Human
Protein ID
NP_000582
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/929
Uniprot URL
https://www.uniprot.org/uniprot/P08571
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000591
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000582
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