C1QB (NM_000491) Human Recombinant Protein
Product Specifications
Background
This gene encodes the B-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. [provided by RefSeq, Dec 2016]
Overview
Recombinant protein of human complement component 1, q subcomponent, B chain (C1QB)
Synonyms
Complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, beta polypeptide; complement component C1q, B chain; complement subcomponent C1q chain B; OTTHUMP00000002940
Gene ID
713
UniProt
P02746, A0A024RAB9
Accession Number mRNA
NM_000491
Chromosomal Location
1p36.12
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Complement and coagulation cascades, Prion diseases, Systemic lupus erythematosus
Field of Research
Complement and coagulation cascades, Prion diseases, Systemic lupus erythematosus
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Secreted Protein
Molecular Weight
26.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
C1QB
Species
Human
Protein ID
NP_000482
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/713
Uniprot URL
https://www.uniprot.org/uniprot/P02746
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000491
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000482
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