ACCN4 (ASIC4) (NM_182847) Human Recombinant Protein
Product Specifications
Background
This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. [provided by RefSeq, Feb 2012]
Synonyms
ACCN4; BNAC4
Gene ID
55515
UniProt
Q96FT7
Accession Number mRNA
NM_182847
Chromosomal Location
2q35
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Ion Channels: Other
Molecular Weight
69.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ASIC4
Species
Human
Protein ID
NP_878267
Overview
Recombinant protein of human amiloride-sensitive cation channel 4, pituitary (ACCN4), transcript variant 2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/55515
Uniprot URL
https://www.uniprot.org/uniprot/Q96FT7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_182847
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_878267
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