ROC2 (RNF7) (NM_014245) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII) . The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1 (CDKN1B) . Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Synonyms
CKBBP1; rbx2; ROC2; SAG
Gene ID
9616
UniProt
Q9UBF6
Accession Number mRNA
NM_014245
Chromosomal Location
3q23
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Ubiquitin mediated proteolysis
Field of Research
Ubiquitin mediated proteolysis
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
12.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
RNF7
Species
Human
Protein ID
NP_055060
Overview
Recombinant protein of human ring finger protein 7 (RNF7), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9616
Uniprot URL
https://www.uniprot.org/uniprot/Q9UBF6
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014245
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055060
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