SF3A3 (NM_006802) Human Recombinant Protein
Product Specifications
Background
This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Synonyms
PRP9; PRPF9; SAP61; SF3a60
Gene ID
10946
UniProt
Q12874
Accession Number mRNA
NM_006802
Chromosomal Location
1p34.3
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Spliceosome
Field of Research
Spliceosome
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Molecular Weight
58.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SF3A3
Species
Human
Protein ID
NP_006793
Overview
Recombinant protein of human splicing factor 3a, subunit 3, 60kDa (SF3A3)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/10946
Uniprot URL
https://www.uniprot.org/uniprot/Q12874
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_006802
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_006793
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