TLE 1 (TLE1) (NM_005077) Human Recombinant Protein
Product Specifications
Background
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.[UniProtKB/Swiss-Prot Function]
Synonyms
ESG; ESG1; GRG1
Gene ID
7088
UniProt
Q04724, Q59EF7
Accession Number mRNA
NM_005077
Chromosomal Location
9q21.32
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Transcription Factors
Molecular Weight
83 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TLE1
Species
Human
Protein ID
NP_005068
Overview
Recombinant protein of human transducin-like enhancer of split 1 (E (sp1) homolog, Drosophila) (TLE1)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7088
Uniprot URL
https://www.uniprot.org/uniprot/Q04724
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005077
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005068
Curated Selection
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