Ku70 (XRCC6) (NM_001469) Human Recombinant Protein
Product Specifications
Background
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V (D) J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human X-ray repair complementing defective repair in Chinese hamster cells 6 (XRCC6)
Synonyms
CTC75; CTCBF; G22P1; KU70; ML8; TLAA
Gene ID
2547
UniProt
P12956, A0A024R1N4, Q6FG89
Accession Number mRNA
NM_001469
Chromosomal Location
22q13.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Non-homologous end-joining
Field of Research
Non-homologous end-joining
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transcription Factors
Molecular Weight
69.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
XRCC6
Species
Human
Protein ID
NP_001460
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/2547
Uniprot URL
https://www.uniprot.org/uniprot/P12956
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001469
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001460
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