HIPPI (IFT57) (NM_018010) Human Recombinant Protein
Product Specifications
Background
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity) . Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.[UniProtKB/Swiss-Prot Function]
Synonyms
ESRRBL1; HIPPI; MHS4R2; OFD18
Gene ID
55081
UniProt
Q9NWB7
Accession Number mRNA
NM_018010
Chromosomal Location
3q13.12-q13.13
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Huntington's disease
Field of Research
Huntington's disease
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
48.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
IFT57
Species
Human
Protein ID
NP_060480
Overview
Recombinant protein of human intraflagellar transport 57 homolog (Chlamydomonas) (IFT57)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/55081
Uniprot URL
https://www.uniprot.org/uniprot/Q9NWB7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_018010
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_060480
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![2-[ (4-Phenyl-2-quinazolinyl) amino]ethanol](https://cdn.genprice.uk/genprice/genprice3.png)
![2-[ (4-Phenyl-2-quinazolinyl) amino]ethanol](https://cdn.genprice.uk/genprice/genprice5.png)
NB120-6111 0.25 mg
Goat Polyclonal Goat F(ab')2 anti-Rabbit IgG Secondary Antibody [Biotin]
Ask
View Details