HIPPI (IFT57) (NM_018010) Human Recombinant Protein

Product Specifications

Background

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity) . Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.[UniProtKB/Swiss-Prot Function]

Overview

Recombinant protein of human intraflagellar transport 57 homolog (Chlamydomonas) (IFT57)

Synonyms

ESRRBL1; HIPPI; MHS4R2; OFD18

Gene ID

55081

UniProt

Q9NWB7

Accession Number mRNA

NM_018010

Chromosomal Location

3q13.12-q13.13

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Huntington's disease

Field of Research

Huntington's disease

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome

Molecular Weight

48.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.