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Beta glucuronidase (GUSB) (NM_000181) Human Recombinant Protein

Product Specifications

Background

This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]

Overview

Recombinant protein of human glucuronidase, beta (GUSB)

Synonyms

BG; MPS7

Gene ID

2990

UniProt

P08236

Accession Number mRNA

NM_000181

Chromosomal Location

7q11.21

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Drug metabolism - other enzymes, Glycosaminoglycan degradation, Lysosome, Metabolic pathways, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Starch and sucrose metabolism

Field of Research

Drug metabolism - other enzymes, Glycosaminoglycan degradation, Lysosome, Metabolic pathways, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Starch and sucrose metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

72.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

GUSB

Species

Human

Protein ID

NP_000172

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/2990

Uniprot URL

https://www.uniprot.org/uniprot/P08236

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000181

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000172

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