Beta glucuronidase (GUSB) (NM_000181) Human Recombinant Protein
Product Specifications
Background
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]
Overview
Recombinant protein of human glucuronidase, beta (GUSB)
Synonyms
BG; MPS7
Gene ID
2990
UniProt
P08236
Accession Number mRNA
NM_000181
Chromosomal Location
7q11.21
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Drug metabolism - other enzymes, Glycosaminoglycan degradation, Lysosome, Metabolic pathways, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Starch and sucrose metabolism
Field of Research
Drug metabolism - other enzymes, Glycosaminoglycan degradation, Lysosome, Metabolic pathways, Pentose and glucuronate interconversions, Porphyrin and chlorophyll metabolism, Starch and sucrose metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
72.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
GUSB
Species
Human
Protein ID
NP_000172
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/2990
Uniprot URL
https://www.uniprot.org/uniprot/P08236
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000181
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000172
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