TGM1 (NM_000359) Human Recombinant Protein
Selected Variant
PH39785M5
Size: 20 µg
Product Specifications
Background
The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE) . [provided by RefSeq, Jul 2008]
Overview
Recombinant protein of human transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) (TGM1)
Synonyms
ARCI1; ICR2; KTG; LI; LI1; TGASE; TGK
Gene ID
7051
UniProt
P22735
Accession Number mRNA
NM_000359
Chromosomal Location
14q12
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
89.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TGM1
Species
Human
Protein ID
NP_000350
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7051
Uniprot URL
https://www.uniprot.org/uniprot/P22735
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000359
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000350
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