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Beta Sarcoglycan (SGCB) (NM_000232) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008]

Synonyms

A3b; LGMD2E; LGMDR4; SGC

Gene ID

6443

UniProt

Q16585, Q5U0N0

Accession Number mRNA

NM_000232

Chromosomal Location

4q12

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), Viral myocarditis

Field of Research

Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), Viral myocarditis

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Function

Druggable Genome, Transmembrane

Molecular Weight

34.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

SGCB

Species

Human

Protein ID

NP_000223

Overview

Recombinant protein of human sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (SGCB)

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/6443

Uniprot URL

https://www.uniprot.org/uniprot/Q16585

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000232

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000223

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