LOX 1 (OLR1) (NM_002543) Human Recombinant Protein
Product Specifications
Background
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Overview
Recombinant protein of human oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1)
Synonyms
CLEC8A; LOX1; LOXIN; SCARE1; SLOX1
Gene ID
4973
UniProt
P78380, A0A024RAU0
Accession Number mRNA
NM_002543
Chromosomal Location
12p13.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
PPAR signaling pathway
Field of Research
PPAR signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Activity
28377266
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Secreted Protein, Transmembrane
Molecular Weight
30.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
OLR1
Species
Human
Protein ID
NP_002534
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4973
Uniprot URL
https://www.uniprot.org/uniprot/P78380
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002543
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002534
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