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C4BPA (NM_000715) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]

Overview

Recombinant protein of human complement component 4 binding protein, alpha (C4BPA)

Synonyms

C4BP; PRP

Gene ID

722

UniProt

P04003

Accession Number mRNA

NM_000715

Chromosomal Location

1q32.2

Expression System

HEK293T

Tag

C-Myc/DDK

Related Pathways

Complement and coagulation cascades

Field of Research

Complement and coagulation cascades

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Molecular Weight

61.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

C4BPA

Species

Human

Protein ID

NP_000706

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/722

Uniprot URL

https://www.uniprot.org/uniprot/P04003

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000715

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000706

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