SHKBP1 (NM_138392) Human Recombinant Protein
Product Specifications
Background
Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.[UniProtKB/Swiss-Prot Function]
Overview
Recombinant protein of human SH3KBP1 binding protein 1 (SHKBP1)
Synonyms
PP203; Sb1
Gene ID
92799
UniProt
Q8TBC3
Accession Number mRNA
NM_138392
Chromosomal Location
19q13.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Ion Channels: Other
Molecular Weight
76.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
SHKBP1
Species
Human
Protein ID
NP_612401
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/92799
Uniprot URL
https://www.uniprot.org/uniprot/Q8TBC3
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_138392
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_612401
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