CA12 (NM_001218) Human Recombinant Protein
Product Specifications
Background
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]
Synonyms
CA-XII; CAXII; HsT18816; T18816
Gene ID
771
UniProt
O43570
Accession Number mRNA
NM_001218
Chromosomal Location
15q22.2
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Nitrogen metabolism
Field of Research
Nitrogen metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome, Transmembrane
Molecular Weight
36.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CA12
Species
Human
Protein ID
NP_001209
Overview
Recombinant protein of human carbonic anhydrase XII (CA12), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/771
Uniprot URL
https://www.uniprot.org/uniprot/O43570
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001218
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001209
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